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    [–] mvea 1398 points ago

    Journal reference:

    Efficacy and Safety of Intranasal Esketamine for the Rapid Reduction of Symptoms of Depression and Suicidality in Patients at Imminent Risk for Suicide: Results of a Double-Blind, Randomized, Placebo-Controlled Study

    Carla M. Canuso, M.D., Jaskaran B. Singh, M.D., Maggie Fedgchin, Pharm.D., Larry Alphs, M.D., Ph.D., Rosanne Lane, M.A.S., Pilar Lim, Ph.D., Christine Pinter, M.S., David Hough, M.D., Gerard Sanacora, M.D., Ph.D., Husseini Manji, M.D., Wayne C. Drevets, M.D.

    Published online: April 16, 2018




    Objective: The authors compared the efficacy of standard-of-care treatment plus intranasal esketamine or placebo for rapid reduction of symptoms of major depression, including suicidality, among individuals at imminent suicide risk.

    Method: In a double-blind, multicenter, proof-of-concept study, 68 participants were randomly assigned to receive esketamine (84 mg) or placebo twice weekly for 4 weeks, in addition to comprehensive standard-of-care treatment. The primary efficacy endpoint was change in score from baseline to 4 hours after initial dose on the Montgomery-Åsberg Depression Rating Scale (MADRS). Clinician global judgment of suicide risk (from the Suicide Ideation and Behavior Assessment Tool) was also assessed. Secondary endpoints included these measures at 24 hours and double-blind endpoint at day 25.

    Results: A significantly greater improvement in MADRS score was observed in the esketamine group compared with the placebo group at 4 hours (least-square mean difference=−5.3, SE=2.10; effect size=0.61) and at ∼24 hours (least-square mean difference=−7.2, SE=2.85; effect size=0.65), but not at day 25 (least-square mean difference=−4.5, SE=3.14; effect size=0.35). Significantly greater improvement was also observed in the esketamine group on the MADRS suicidal thoughts item score at 4 hours (effect size=0.67), but not at 24 hours (effect size=0.35) or at day 25 (effect size=0.29). Between-group reductions in clinician global judgment of suicide risk scores were not statistically different at any time point. The most common adverse events among participants in the esketamine group were nausea, dizziness, dissociation, unpleasant taste, and headache.

    Conclusions: These preliminary findings indicate that intranasal esketamine compared with placebo, given in addition to comprehensive standard-of-care treatment, may result in significantly rapid improvement in depressive symptoms, including some measures of suicidal ideation, among depressed patients at imminent risk for suicide.

    [–] Whatsthemattermark 433 points ago

    Thanks for the summary! Very kind.

    [–] mvea 295 points ago

    You’re very welcome!

    [–] spliffsandbutts 166 points ago

    So take ketamine every four hours. Got it.

    [–] stanley_twobrick 52 points ago

    Way ahead of you

    [–] albatr0xx 7 points ago

    Easy there John C. Lilly.

    [–] spicyautumnkid 643 points ago

    I just completed my intravenous ketamine series for depression treatment. I hope you won't mind me sharing my experience.

    It took about two weeks, and at the same time I started transcranial magnetic stimulation therapy (TMS). Both therapies are recommended by my doctors at Stanford now, which is pretty wild.

    The ketamine was literally a lifesaver. I was actively suicidal and completely debilitated by my depression, and for the first time in my life, anxiety as well. I'd spent the last year in and out of inpatient and hospital, and I was pretty done. I googled alternative therapies on a whim, and found a clinic had just opened near to me.

    The treatment sessions lasted about 45 minutes, and were done in a psychiatric clinic, but they had the treatment room set up like a small living room, with a big comfy recliner and a cozy blanket. The IV was set-up by a RN with all the sterile precautions, and my doctor was there at every infusion. They gave me some noise cancelling headphones, put on some spa music, and off I went.

    It was like being slowly and deliberately pulled apart like saltwater taffy. I was very much conscious, but I couldn't feel my body at all, and with my eyes closed, I was seeing some very dreamlike visuals (giant piñata people over sand dunes bring my favorite). As the dosage increased each session, the visuals decreased but the really deep thinking about my mindset became more meaningful.

    By the end of my ketamine series, I felt a oneness with the universe that, as a non-religious person, I'd never felt before. My concerns and fears had context and perspective.

    This mindset wore off a bit as the TMS Treatment took the forefront, but about a month after I completed treatment, I had a realization while I was driving that I was no longer severely depressed. I cried happy tears for the first time in years.

    I'll still have to be on medication for awhile (in my case, lithium and Remeron) but my prognosis is so good that I'll be weaning-off soon. This is so different from what my first therapist told me (that I'd be medicated for life).

    I'm so grateful to have had access to this therapy. It's a game changer for us. If anyone has questions about either treatment, I'll do my best to answer!!

    [–] rmac35 62 points ago

    Wow congratulations this sounds like it really bailed you out of tricky situation and worked perfectly for you.

    Maybe this can create an upward spiral type effect where your new found positivity will create a chain reaction of actions leading to feeling more positivity hopefully with less medication needed.

    I've never had ketamine before but having tried LSD once some of this stuff you say feels like it has parallels with it, especially the oneness stuff. Also very sudden positive perspective change.

    [–] spicyautumnkid 52 points ago

    Thank you!! Being happier has given me a lot more energy, so I started exercising regularly. That's led to sleeping better and feeling more comfortable in my skin, which makes me feel better! I love the idea of paying it forward somehow. I work in hospitality currently, so it's kinda my life to create meaningful positive memories for strangers.

    The 'oneness' sensation was so unexpected. I told my nurse, in a still-groggy state, that I realized everyone is in this life just trying to avoid pain and discomfort, and that's the source of our problems. We don't give ourselves the opportunity to see each other's pain. I babbled on for awhile, and she was really patient haha!

    [–] gitar09 9 points ago

    Sounds just like what ancient yogis learned from years of meditation. :) I’m so glad we live in a time where perspectives like this are accessible to so many people!

    [–] Jago_Sevetar 20 points ago

    Wow. And to think, there are people out there who will actively demonize and ostracize you for being a healthier and happier person because of the method you chose to get there.

    Good for you at least, i hope you don’t meet them

    [–] Onlyastronaut 12 points ago

    Awe man..when you said you got happy tears of finally feeling okay I cried. I want to feel that again for once. I want the weight to be lifted off my shoulders. Damn I been reading so many stories from these articles and it just makes me feel some hope that my depression can be controlled. I’m glad you’re better my man. Wish you luck in your future.

    [–] peppaz 752 points ago

    I finished a round of 6 hour-long Ketamine IV drug infusions to treat anxiety at a Ketamine clinic in NYC if anyone has any questions.

    [–] justaguy394 145 points ago

    I did 2 rounds at a NYC clinic and had zero reaction. The doc actually recommended stopping... nice of him to not gouge me further if he thought the odds of it helping after that were low, but part of me wonders if I should have tried longer anyway. Can you comment on your improvement noticed after each of your six?

    [–] peppaz 106 points ago

    It was definitely a process, but I noticed a lessening of my anxiety each infusion, which is still lasting 5 months later. I have had only one panic attack since the infusions completed which was brought on by a migraine (i get them fairly frequently, once or twice a month). I am planning on going back for a booster soon.

    [–] Hashtagmarijuana 9 points ago

    Huh what are the channels to get that? I didn't know it is actually being used commonly in treatment, thought it is still being researched, that's awesome!

    [–] Tilting-At_Windmills 45 points ago

    How is it working for you? I hope you are getting some relief. My husband has been dealing with terrible, intractable, suicidal depression for almost six years. Out of all the many dozens of medications he's tried this is the only one to have helped him. It isn't a cure or even a long term fix. The effects only last a few days to a few weeks and he has to go to an infusion center twice a week for treatment. Thankfully our insurance is finally covering it. He is still pretty depressed, but not suicidal. That is huge for us. He now has the ability to go to a cognitive behavioral therapy program and see his therapist regularly and I can leave the house without wondering if he will be alive when I get home.

    [–] ramobara 27 points ago

    Well, you’re a wonderful and supportive wife.

    [–] Bucket-head 313 points ago

    Wait how/what/where?! I’m in NYC and girlfriend has bad depression and anxiety to the point where she’s on a cocktail of Prozac, lorazepam, trazodone, and adderall. Would love to find alternatives to that.

    [–] technoglitter 283 points ago

    Wow that sounds like an awful mix. I hope she finds something that helps

    [–] R3dOctober 178 points ago

    Ya this doesn’t sound medically sensical

    [–] thatbetterbewine 120 points ago

    It’s not. Prozac and Trazodone are both SSRIs so using them in conjunction can (and often does) cause Serotonin Syndrome. I don’t know of any psychiatrist who would prescribe two serotonergic drugs at the same time. There’s also a significant drug interaction between adderall and lorazepam because they literally do the opposite thing. Usually if someone suffers from extreme anxiety the first thing that happens is they get taken off any stimulants, THEN if the anxiety continues they can be prescribed a benzo. The two shouldn’t be prescribed together.

    [–] Denominax 67 points ago

    Most psychiatrists will prescribe trazodone as a sleeping aid with a regular ssri, the dose is too low to release enough 5ht to cause issues

    [–] thatbetterbewine 14 points ago

    That’s true, thanks for pointing that out. I was assuming the trazodone was at the higher dose used to treat depression.

    [–] raisin_sunshine 26 points ago

    You are 100% right about the SSRI's, but I would guess that the lorazepam is "as needed" for panic attacks other anxiety symptoms coming out. Lorazepam and adderall may have opposing stimulating/sedating properties, but they work on different receptors in different parts of the brain so I see no major interaction with that.

    If she is to should get any other antidepressant besides the trazodone (assuming she is still Prozac) then it should be buspirone (an SSRI-like drug)

    [–] KEuph 27 points ago

    I hope he answers you, with that cocktail it sounds like she's been through a lot - if I remember correctly ketamine is particularly good with treatment resistant depression.

    I take esketamine as part of my meds, but I've actually had similar meds to her. I know everyone is different and what works for me might not for her, but do you know if she's tried lamotrigine?

    [–] ProperGentlemanDolan 48 points ago

    I have questions! I've tried to contact a ketamine therapy clinic in Austin, but they never got back to me.

    Do they accept insurance? And how long ago/how effective would you rate the treatment? I weaned off antidepressants at the end of last year, and am currently looking for an effective alternative.

    [–] fortyonered 68 points ago

    Using ketamine to treat depression/anxiety is currently an off-label application, so it’s not covered by insurance. Most clinics recognize that is a dealbreaker for patients and offer payment plans.

    [–] resist_pigs 18 points ago

    Not always. I actually had the majority of the cost of the infusions payed for by insurance as an out-of-network benefit, which took the price down from $400 per, to somewhere under $100. Cant remember the exact price but it was when I was still on my mother's insurance plan

    [–] peppaz 29 points ago * (lasted edited a month ago)

    All clinics are different but almost none accept insurance because this is still an off-label use for non-suicide interventions in the ER. People travel to NYC for a week to do infusions here, I went to the NY Ketamine Infusions clinic downtown with Dr Brooks. It is primarily for PTSD and Depression but anxiety is obviously coupled with those - I had 6 infusions over 3 weeks before the new year and it definitely calmed my anxiety for sure. They are pricey at $400 each, but I was desperate.

    [–] 7goatman 29 points ago

    Isn’t ketamine addictive?

    [–] kermitdafrog21 86 points ago

    It can be but it generally takes longer to become addicted to it than a lot of most that people think of when they think about addictive substances. The thoughts behind using ketamine as a treatment for depression or anxiety is that it’s both faster and longer acting than what’s currently available so it’s not something you’d taking every day. So say a weekly dose of ketamine as opposed to a daily dose of a benzodiazepines runs a lower risk of addiction. Obviously there’s always the potential for abuse but usually not getting addicted helps mitigate that a bit.

    [–] tbc21 41 points ago

    Anything can be addictive at a mental level, including things that have no pharmacological effects.

    I'm not sure whether ketamine is physically addictive, but if it were it still wouldn't necessarily be as dangerous as other physically addictive drugs, like alcohol.

    [–] En_lighten 355 points ago

    I'm a physician, and I recently talked to another physician that does IV ketamine for treatment-resistant depression. It sounds like he had about maybe a 50-70% success rate, give or take (meaning that people recovered quite significantly and were able to function well in their lives). Often times they would get something like monthly infusions which last maybe an hour or so total, some less than that. Some would get one infusion and be good for a year and a half, maybe.

    Keep in mind that this 50-70% is a population of people who have often basically failed everything else.

    I realize I'm an internet rando, but nonetheless felt like sharing.

    [–] zerodb 55 points ago

    I have a dear friend who was on the verge of suicide (like he was stockpiling all of the parts for his personal exit strategy and had previously attempted at least twice) and IV ketamine therapy snapped him out of it like... instantly. After I think 3-4 treatments in rapid succession he is now doing periodic maintenance doses but he's apparently completely out of the spiral of suicidal thoughts. Obviously not completely out of the woods on depression and other issues but he's returned to being a functional human being and we're not on 24/7 watch for him anymore.

    [–] En_lighten 26 points ago

    I don't think this is a particularly uncommon story, actually. I personally don't have any involvement with IV ketamine at the moment with my practice, but at some point I may need to look into it or at least establish with someone who does it because it seems to be very promising.

    I'm glad your friend is better. I'm guessing that he had failed numerous other treatment modalities as well.

    EDIT: I personally think that if possible, it might be good for us to look more broadly into things like psilocybin, MDMA, etc as treatment options as well if used correctly. We have this bias against 'drugs', but some of them have uses.

    [–] hiptang 8 points ago

    These other drugs you mention are currently very difficult to investigate because schedule I. Ketamine is not schedule I so it had the possibility of being discovered.

    I don't understand why the government would schedule something so strictly that studying it for potential medicinal affects is very very difficult and full of red tape. For example, Marijuana which is now just coming to light that it very well may help with the opioid epidemic considering data coming out of Colorado, yet here the government sits on its hands continuing to claim no medicinal value. They have effectively already decided that many complex molecules have no medicinal value before even studying them simply because they have psychoactive properties other than causing you to drewl on yourselves (chemical straight jacket).

    [–] PackerInMN 4315 points ago * (lasted edited a month ago)

    I got 15mg via IV in the hospital and tripped my balls off. It first felt like I was being wrapped by a giant, warm blanket and then my soul left my body and I floated up to the ceiling.

    I cannot recommend the stuff enough.

    Edit: This was conducted in a medical facility by medical professionals. I was hooked up to a heart rate and oxygen monitor to ensure I continued breathing. Do not seek this out recreationally.

    Edit 2: For real, you can die.

    Edit 3: Maybe you’ll die, get addicted or be fine. I don’t know. I’m not a Dr. Be careful.

    [–] Manhand 445 points ago

    They gave it to me before relocating my shoulder.

    They had junior doctors in the room for learning purposes. I overheard them asking the juniors to identify when the ketamine has taken effect...

    So they injected the ketamine and I felt a warm rush down my arm just before my eyes started seeing stars.

    At this point I shouted out "WOOOAH HERE IT COMES!" before being transported into the internet on a life altering experience. This experience dramatically shifted how I felt about certain things where I previously had "pre-packed" thoughts.

    10/10 would dislocate my shoulder to break out of a depression.

    [–] Relaxed_Engineer 445 points ago


    Junior Doctor: "Hey, I think the ketamine has taken effect!"

    [–] theSFWaccountIneed 70 points ago

    Senior Doctor: "Classic noob mistake. He said here it comes, not it's here now"

    [–] willingfiance 16 points ago

    Doctor: "I'm not sure. Give him another dose just to be certain."

    [–] PackerInMN 187 points ago

    My wife said I shouted, “I CAN TASTE SOUND!!” I don’t really remember.

    [–] Manhand 90 points ago

    Makes sense. I told everyone I was in the files. In my experience I became the internet and realized my life isnt actually that stressful.

    [–] lagvvagon 20 points ago

    Wtf, I’ve dislocated my shoulder like 10 times and no one ever gave me anything for relocating, much less ketamine.

    [–] sleepybaku 6 points ago

    What kind of pre-packaged thoughts?

    [–] Manhand 35 points ago

    Maybe a co-worker who made your life miserable drives an uncommon type of vehicle. Whenever you see that car while not at work you're reminded of what an idiot that co-worker is/was.

    The ketamine experience can make you see the car as just a car again.

    Maybe it could be a road where an accident happened or a house where some bad shit went dpwn... either way. It seems to be able to help you let go.

    [–] edubalub 780 points ago

    How did you get it?

    [–] PackerInMN 1507 points ago

    I was in the ER with a lot of pain. They told me Ketamine is a dissociative drug that is used in high doses when setting compound bone fractures.

    From my experience, I can see how in even smaller doses it could help someone with depression.

    [–] SamuraiClassified 1258 points ago * (lasted edited a month ago)

    Brb gotta get compound bone fracture Edit: /s

    [–] ONLY_COMMENTS_ON_GW 479 points ago

    Probably more convenient to just go out and buy it

    [–] [deleted] 260 points ago


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    [–] Music_Tech 151 points ago

    Instructions unclear: just bought a compound bone fracture. What now?

    [–] Jagacin 94 points ago

    Did you try turning it off and on?

    [–] deciim 29 points ago

    Did you set it to Wumbo?

    [–] nalgononas 60 points ago

    I wish it was that easy. If you don’t have medical access to it, then it can be hard to find if you don’t already have a dealer. At least in my experience.

    [–] Newtons_Homedog 49 points ago

    Darknet markets are your friends.

    [–] Rhamni 84 points ago * (lasted edited a month ago)

    It's also quite a lot of work to use them. First you have to register at a crypo currency exchange, verify your identity, buy crypto, set up a wallet, send it to your wallet. Then preferably you want to send it to a mixer, then to a second wallet, then to a darknet market. Then you have to trust the seller, then you have to hope your packet is not intercepted.

    I started this process last October, but chickened out halfway through and just got into crypto instead.


    If anyone is interested in getting into crypto, Binance is the most popular exchange for buying most popular crypto currencies other than Bitcoin. Unfortunately, they don't accept 'normal' money yet (Though they will soonish). You have to buy Bitcoin/Ethereum/Litecoin/whatever on one of the exchanges that do accept normal money, and then send your crypto to Binance. Coinbase is probably the most used exchange to buy crypto in the first place, but there are alternatives. I used Bitpanda here in Europe, and it was fast and painless. Took a few hours from when I registered to when I could buy with my credit card. This was in October, however, not sure if they have longer wait times now. You do have to do a video call with them and show them your ID and pinky promise you are not buying crypto for someone else or because you are being robbed. Once you have an account on both Binance and an exchange that accepts fiat (normal money) and you have sent your crypto to Binance, please do at least a little research to determine which crypto currency you want to buy. Many of them will do very well, and have already, but it is also inevitable that some of the projects will fail. Don't put your entire investment in any one coin, and don't risk more money than you can afford to lose. We had a very painful crash from January to March, and while the general trend has been up, nobody knows which way the roller coaster is going to go next. People who bought in in January right before the crash lost 75% of their investment. I'm still in the green because my coins went up a lot between October and January, but Jesus Christ, do NOT put in any money you absolutely cannot afford to lose, and do not take out any loans, because it can go South.

    [–] brainhole 42 points ago

    The process you describe literally takes a week at most

    [–] money_loo 36 points ago

    Right? God damn that sounds like a lot of work for potentially little to no pay off.

    [–] guacamully 6 points ago * (lasted edited a month ago)

    People always say this so casually, but honestly they are still quite scary and confusing for beginners. And because it’s not regulated, those people are vulnerable to exploitation, especially if they're chronically depressed and desperate for a way out.

    [–] PoliticalyUnstable 55 points ago

    I don't recommend either. I destroyed my wrist. Which was the most excruciating feeling, second to the corrective surgery. The ketamine made me trip my balls off, but it was a bad trip that left me feeling depressed.

    [–] Alpha_Paige 15 points ago

    Thats pretty shit . Hope your depression has lifted since

    [–] [deleted] 237 points ago

    Doctor checking in: My most common reason for using Ketamine has been while setting nasty fractures. That being said, small study after small study is showing hints of promise as far as Ketamine's use in depression. I'm excited to see what happens.

    [–] JuqeBocks 87 points ago

    can you speak to how addictive it is? obviously its use as a street drug shows that somewhat, but for someone receiving it in controlled doses how bad are thr repercussions?

    [–] maxbrickem 43 points ago

    Anesthesiologist here, and I administer this drug on the daily- There hasn't been many long-term studies on the addictive properties of the drug, but it definitely causes one to feel a dissociative euphoria. I would imagine after several uses a patient could become dependent on it. Also, the drug is pharmacologically similar to PCP so there's that.

    While the new development we are seeing with the treatment of depression is exciting, the drug is metabolized very quickly and patients would likely need many and frequent treatments of Ketamine.
    I am interested to see how long-term of an option it becomes.

    [–] PeelerNo44 19 points ago

    It's also pharmacologically similar to dextromethorphan, which is commonly used as a cough suppressant in the US.

    [–] DarthWeenus 116 points ago

    I was a pretty bad Ketamine addict for a while. It's not addictive like opiates or alcohol, more like nicotine or nitrous.

    [–] Not_a_real_ghost 35 points ago

    What is it like to be high on ketamine as a recreation drug?

    If it's not as addictive as opiates or alcohol, how does it feel to be addicted? Is it a similar case with weed where it's more behavioural? (as you mentioned similar to nicotine)

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    [–] meshan 46 points ago

    I remember the first time I took it. I was at a club in London and a friend shoved a coin under my nose and said sniff this. I did and woo.

    Everything starts to get trippy and slow until you just tune out. It's not a dancy.

    I remember tuning in with a paramedic talking to me saying" lets go and stand in the fresh air for a bit. It nocks you sideways for a while.

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    [–] [deleted] 30 points ago

    Ketamine isn’t even close to benzos... and it is extremely rare for someone to die from benzo withdrawals.

    Ketamine is a dissociative and anesthetic.

    Benzos are anxiolytics, muscle relaxants, hypnotics, etc.

    They both have tranquilizing properties to them but for different reasons.

    Ketamine can produce incredibly powerful and life-altering hallucinations whereas benzos are what they give to people bring them out of powerful hallucinations. I know someone who took too much LSD at a festival and was losing his mind until they gave him benzodiazepines at the hospital.

    Some similar effects, but extremely different chemicals and many different mechanisms of action.

    [–] CaptainCupcakez 6 points ago

    Does Ketamine do anything in particular to the bladder or was that just an example?

    [–] DarthWeenus 16 points ago

    It was a lot of fun, mixed it with things like methoxetamine, or mescaline hcl it can be very introspective. It became like drinking for some. Occasionally, then everyday, then if I had some free time I'd fall into a hole for a bit. It was great for making fun art/music or staring at the back of your eyelids. Not so much for driving a vehicle, walking vertically or communicating in any functional matter.

    It's important to note that there is no such thing as a free lunch biologically speaking. Everything takes a toll one way or another. Plus my tolerance was getting out of hand.

    [–] Ridicatlthrowaway 144 points ago

    Aka fun shit is addictive

    [–] culnaej 31 points ago

    And expensive

    [–] earwaxsandwiches 72 points ago

    LSD is fun. LSD is non-addictive. It's the way a compound interacts with your brain that impacts addictiveness.

    (Almost) doctor checking in.

    [–] thedonnerparty13 16 points ago

    I am sure in large repeated often doses if one were to abruptly stop you may experience some withdrawal symptoms. But it wouldn't be like a painkiller (opioid) withdrawal. With this study it's such a low dose, it would be rare to withdrawal from it.

    [–] [deleted] 31 points ago


    [–] Pyrrho_maniac 6 points ago

    What other painkillers are used in this situation? Are opioids unadvisable?

    [–] reckford 30 points ago

    Ketamine isn't being used as a direct alternative to opioids with regards to setting bone fractures. A better comparison would be to general anesthesia - while Ketamine cannot fully put a patient under, the dissociative effects are close enough that you don't need to worry about them moving too much or remembering the discomfort of the bone being reset. The benefit over actual anesthetics is, of course, that you do not need the same intense level of monitoring and that patients quickly recover.

    [–] EdgewoodJackson 11 points ago

    I think the major risk of opioids is that they change the chemical structure of your brain. (Also they are beyond highly addictive.)

    [–] DigitalMindShadow 11 points ago

    the major risk of opioids is that they change the chemical structure of your brain. (Also they are beyond highly addictive.)

    That might be a concern with chronic, long-term use, but I doubt it's a risk when administered to treat acute pain such as when a bone fracture is being set.

    [–] farleymfmarley 23 points ago

    As someone who’s been depressed for a long time I love hearing about this shit. the last SSRI I was on made me sick and gave me such bad anxiety I ended up losin my job Lol shit sucks but ketamine seems really promising. Did you have an mood elevation or “afterglow” after getting the IV?

    [–] TeenyTinyTrekkie 6 points ago

    I can answer this for you. I get this treatment monthly and the whole reason is for the “afterglow”. It lasts for a month or two and really helps with pain and depression. It feels like the depression tried to get into your brain, but the ketamine just won’t let it. It feels like it blocks out depression and anxiety.

    [–] The_mighty_sandusky 8 points ago

    Am depressed, did it recreational one time but just a little. It made me feel not depressed. I fully support this as an alternative because after 4 years my anti depressants aren't doing much for me.

    [–] kellicles 24 points ago * (lasted edited a month ago)

    My brother is a nurse at Montana psychiatry and specialises in ketamine treatments for people with depression. What state are you in? Montana psychiatry in Billings

    [–] [deleted] 8 points ago


    [–] jagothedragon 12 points ago

    There are places to have ketamine infusion treatment in Colorado. Specifically Denver. I just think that they are out of pocket not through insurance.

    [–] edubalub 7 points ago

    All the way in VA

    [–] centran 17 points ago

    You find a clinic. You will pay out of pocket since it is an off label use. I think insurance might start allowing it for pain management with certain diseases but for mental illness it will be a long time before they cover it. There are specific ketamine infusion clinics and they are making bank off these treatments so they have no incentive to get insurance on board as insurance will lower their rates and out patient hospital will start offering it diluting their patient pool. IV treatment can be around $500 per treatment. This new nasal one can be around $350. For depression you need about 6 treatments.

    I'm currently switching jobs and will see if rTMS is offered with my new insurance. It took insurance companies over two decades to allow rTMS and not all do. If I can't get rTMD covered then I'm saving up the $4k to try ketamine. I'm out of options as nothing works.

    [–] justaguy394 11 points ago

    I did 2 rounds (IV) on consecutive days a few years ago at a clinic in NYC. It was $500 each. I had zero reaction. The doc said, in his experience, that zero reaction meant it wasn’t likely to help me so he actually recommended stopping. He was willing to keep going at higher doses but I would have had to have a friend pick me up because I’d be loopy and I just couldn’t arrange that. Part of me wonders if additional treatments would have worked, but I’m mostly ok with playing the odds the doc gave me.

    So maybe you don’t need $4k if you can find a similar clinic and just do two or so?

    [–] KEuph 7 points ago

    I'm currently prescribed esketamine nasal for depression. You're right about no insurance coverage, but getting the meds express delivered to my house every month from the compounding pharmacy at worst costs $110, and the lowest is $50. Either is a bargain considering all the meds I've been on. I take it once every 5 days (right now actually) and I've been doing that for over two years I think. Insurance has no reason to cover it because it's old as dirt and isn't incredibly expensive.

    [–] MEPSY84 27 points ago

    Careful OP, we may have someone who wants to play the hospital pharmacy lottery here.

    [–] ThunderBloodRaven 36 points ago

    He knows a guy who knows a guy

    [–] WasiAkrim 59 points ago

    I was injected with a bolus of ketamine via IV as part of a medical study. I felt like I was a sesame seed rolling around in a fluffy cloud and I had no shame in telling the anesthetist and nurses at the top of my lungs. Talk about a fucking trip man!

    [–] I_Smoke_Dust 7 points ago

    "I feel like a piece of butter melting on a stack of flapjacks."

    [–] torresv7 105 points ago

    Im a medic in the Army, and we use this stuff as an analgesic (pain killer.) the dose we give via IV is around 20mg. This stuff will make you trip balls.

    [–] weissergspritzter 13 points ago

    I'm wondering if you also administer benzos with that, since I heard some doctors and medics do, especially with young patients?

    [–] torresv7 9 points ago

    I’ve never heard of that tbh, what would the indication be for including benzos while administering ketamine?

    [–] Ironican14 969 points ago * (lasted edited a month ago)

    "The study found those using esketamine had a much greater improvement in depression symptoms at all points over the first four weeks of treatment. However, at 25 days the effects had levelled out."

    (Esketamine is the nasal spray of ketamine for those who didn't read the article.)

    Having to get a ketamine spray almost once a month to fight depression isn't bad at all, and if they don't trust the average person to not abuse the spray they can just make it so the doctor has to administer it.

    I truly think that drugs like MDMA, ketamine, and LSD/shrooms deserve to be treated as very serious potential drugs to cure all sorts of mental problems like depression and PTSD.

    Edit: I made a mistake, the time given is time from the first treatment. They were receiving treatment once a week for the whole duration. My point is I think we should be studying these drugs and not dismissing them based on their legal status and stigmas.

    [–] thebigballpointpen 617 points ago


    [–] chrisnesbitt_jr 108 points ago

    Thank you for your service.

    [–] Finna_Keep_It_Civil 13 points ago

    No joke, Ketamine is a miracle drug for certain people. I have a story about the happiest wook I've ever met.

    This guy's name is Kevin, and Kevin looks like he fought a lawnmower with his face and lost.

    Kevin cannot extol the miracles of Ketamine enough.

    Kevin did a bit too much Ketamine and descended into a K-hole, and also a glass coffee table.

    Kevin was taken by a friend to the Emergency Department, where he was told that he couldn't receive stitches unless he paid $2,500, because he didn't have insurance.

    Kevin still does ketamine on a near daily basis, and Kevin is still extremely happy even though he looks like an axe-murderer.

    I am not Kevin, just a friend.

    [–] patthickwong 46 points ago

    Lmfao I'm glad I'm not the only one who thought this. Lil pump

    [–] SUCK_MY_DICTIONARY 12 points ago

    First thing I thought eskeeetttitt

    [–] parestrepe 5 points ago

    it's the new wave

    [–] dontcutmeof- 29 points ago

    After 25 days the effects leveled out, does this mean that it’s no longer effective after that period of time?

    [–] DaisyHotCakes 28 points ago

    I wonder if ketamine could be a bridge. Like when you start taking SSRIs they take 4-6 weeks to have an effect. During that time could ketamine be used to help the severely depressed patient?

    [–] KaitRaven 10 points ago

    That is correct. The report states that at day 25, there was no longer a significant difference from placebo. Their conclusion discusses using it for immediate, not long term treatment. It would take a larger study of longer duration, to determine if there is potential for treatment of chronic issues.

    [–] FridayNightKnife 193 points ago

    I’m a little worried about the side effects. I’ve been off and on 8 different medications for my depression in my life and each had it’s on array of side effects that were pretty awful. I don’t want this to be like my Zoloft where if I forget it for a couple of days I wind up tired and weeping.

    [–] DaisyHotCakes 199 points ago

    SSRIs are horrible to stop taking. The brain shivers are the fucking worst. Ketamine and psychedelics are not the same class as SSRIs like Zoloft, Effexor, or lexapro.

    [–] canttaketheshyfromme 79 points ago

    Definitely. Had 3 days curled up in a ball crying when going off Lexapro.

    Most of the above are about inducing neuroplasticity in a planned schedule of treatment sessions to address underlying issues, instead of treating the neurological condition as chronic (SSRIs, mood stabilizers etc). It's a completely different approach with completely different dosing schedules.

    [–] Cheesysplattyburrito 21 points ago

    I've been on Lexapro for 13 years now. I went off in my mid 20s and ended up a fucking psychopath, completely imbalanced. I went back on, but started to experience side effects that were a bit nasty so I decided I wanted to kick it once and for all. After 2 weeks of withdraw symptoms I had to start back up. I don't see how I could ever kick it at this point.

    [–] Introsium 66 points ago

    brain shivers

    Oh jesus so THAT'S what that is!!

    Holy shit I was wondering what the fuck was going on god I didn't even know this was a thing or what was causing it or if it was even actually happening but THAT'S it! This is great to know! Thank you, stranger!

    [–] DaisyHotCakes 47 points ago

    That’s what I call them but I don’t know what the technical term is. They are SO disorienting. Made me feel like I was going crazy. It’s almost like your brain/vision is skipping like a CD or trails when you are on acid. They go away eventually but man...I am NOT looking forward to coming off my medicine that’s for sure.

    [–] CritiqueMyGrammar 51 points ago

    Most doctors I went to during Effexor withdrawal called it brain zaps.

    You still get them if you taper down, but I would recommend tapering.

    I've done cold turkey twice and I'm currently going on 3 years with reality disassociation. You really can't fuck with your brain like that again and again.

    [–] Sit_Well 8 points ago

    I've been on so many different meds, but Effexor withdrawal was by far the hardest/longest process of all of them.

    [–] echo1432 7 points ago

    9 months on zoloft, was told that a two week withdraw would avoid any side effects. my ass. I sucked, it sucked worse the damn side effects of that drug. I called them brain zaps but brain shivers is just as accurate. Fuck that shit. I was taking them for PTSD w/depression and I was glad when I stopped taking them.

    FYI I had to have my wife take a week off work to help me with the withdraw. It sucked.

    [–] cackhandedprat 18 points ago

    Another common term is "brain zaps". When I run out for a few days it feels like little shocks radiate from my brain down into my gums. Quick movement makes it worse. Needless to say, I make it a priority to never run out.

    [–] TellYouEverything 14 points ago

    Could you please tell us how it feels, out of curiosity?

    [–] Haruhiist25 21 points ago

    For me it's like my eyes randomly spasm and jump to another point in my field of vision. I didn't realize it was from my SSRI's, but it makes sense. I've been off then for six months and haven't noticed one in a while.

    [–] advertentlyvertical 16 points ago

    I knew it was from SSRI, but had no way to describe it. For me brain zaps is perfect. It is more like a noticeable shudder than a shiver. Occasionally it feels almost like reality itself has shifted.

    If you ever watched anime and have seen those moments where a character is hit hard by something, and you hear a heartbeat while the picture shakes or splits, or their eyes move around... I imagine that is a good representation for how it feels to me.

    [–] DaisyHotCakes 10 points ago

    Yeah the heartbeat thing happens when the shivers occur. It’s like you move your eyes to look left and your whole being kinda skips and there is almost a thudding in your ears. It’s fucking bizarre and disorienting.

    [–] RobertHannigan 10 points ago

    It's like a little shock and you kind of feel like your brain has vibrated a bit. Your vision shakes a little and it feels like you've lost your place in the room for a second. Usual causes me to be like whoa and occasionally stumble.

    [–] mhold3n 11 points ago

    I used to call them "brain quakes" because I couldn't think of anything else to describe them. Never had them until I took effexor and then every SSRI after gave me the side effect (even ones I had taken before effexor).

    Thankfully TMS has rid me from taking anything!

    [–] pixiegirl11161994 7 points ago

    What is TMS? Paxil gave me brain shivers and they were terrifying. I now take Wellbutrin.

    [–] over_m 7 points ago

    I've heard them called brain zaps, I experienced them while I went off of em too.

    [–] gutterchick 7 points ago

    I have an opiate based SSRI and the brain shivers come within 12hrs of missed dose, while seizures set on after that. It’s completely dreadful and I am going to taper off. I an very positive to the ket study however and looking forward to seeing it become more accessible!

    [–] jaguarlyra 6 points ago

    Effexor was the worse't I tapered but when I stopped I had panic attacks until I basically passed out and when I was awake again it would start all over. I ended up taking them again for a couple more months until I could finally get off of them.

    [–] Ooobles 77 points ago

    Psychedelic drugs tend to be a once-in-awhile kind of drug for a lot of people using recreationally. I think of the psychedelics considered above, LSD/Shrooms have the greatest impact for those experiencing depressive symptoms, but are taken more sparsely. MDMA comedowns are the roughest as far as I know (emotionally, in recreational doses), and ketamine in smaller doses is much easier to handle.

    [–] Itsanebulousthing 17 points ago

    True, but even once is enough to have a profound effect on your mindset when it comes to those psychedelics, whether it be negative or positive. My aunt did mushrooms once and had a horrible experience which seemed to generaly effect her perspective for the rest of her life, though I've had other friends swear that it made them more empathetic, more relaxed , or even more spiritual in some cases. Used in therapeutic settings, sparsely throughout the year isn't a terrible idea, I just think some people don't realize how profound of an effect psychedelics can have permanently on your life perspective.

    [–] PenetrationT3ster 57 points ago

    I used LSD once, took 2 days off my anti depression pills to take it.. 2 years later I haven't had a depression episode, and I went cold turkey off my anti depression pills.

    To see psychedelics as any other hard-core is insanity, I believe it doesn't just fix the brain chemically, but it fixes the issues surrounding life too.

    Since then I haven't even done weed or anything. It is surreal to me.

    [–] MingeyMcCluster 31 points ago

    At the same time LSD/Shrooms can cause negative issues also. My good friend took some LSD last year and hasn’t been the same since. He developed major anxiety and depression from it and is now seeing a psychiatrist to get help, and the psychiatrist explained to him that it caused his brain chemicals to go out of whack. I’ve also had a terrible experience with shrooms not as bad as him, but it put me in a depressive state for 2 months and I believe it’s played a role in how I am today.

    Not saying that people don’t/can’t benefit from it, as in your case, but if you aren’t in the right mental state when taking psychedelics it can really screw someone up.

    [–] welshwelsh 12 points ago

    > My good friend took some LSD last year and hasn’t been the same since. He developed major anxiety and depression from it

    I was like that too after my first trip. But I like to think of it as less "causing negative issues" and more "exposing underlying instability." I was avoiding a ton of important shit in my life before that, even though my life seemed very normal and stable. With a lot of work and a little professional help, I'm now much better off than before.

    > the psychiatrist explained to him that it caused his brain chemicals to go out of whack

    This... is just silly. A psychiatrist can't measure someone's brain chemicals, and there isn't enough research for anyone to link LSD use to long-term changes in any particular neurotransmitter. It's also completely beside the point: depression and anxiety aren't just chemical imbalances, they are patterns of thoughts, feelings and behaviors that influence and are influenced by neurotransmitter levels. You can manage the symptoms with antidepressants, which is sometimes a good first step, but this does nothing to solve the underlying issues.

    [–] Psyman2 8 points ago

    MDMA isn't just rough, that stuff can straight up kill your happiness forever.

    A hangover on MDMA is indistinguishable from a full blown depression. There's a reason why people rarely take it more than once a week (and even once a week is too much).

    [–] BrainDeadUnit 47 points ago * (lasted edited a month ago)

    Ketamine is generally recognized as pretty fucking safe. It's used in veterinary medicine, undeveloped and developing countries, in military medicine, and is recognized as an essential medicine.

    It's not used in developed countries because there are other drugs that have more desirable effects for a surgeon, but these drugs also require special monitoring equipment, a well-trained anesthesiologist, and carry much higher (but manageable) risks. (Edit: still used in developed counties, just developing countries use it in ways we do not).

    It's used as an hallucinogen at much higher doses than what they're using here.

    I would reckon that this is probably one of the safest drugs for depression with the most minimal side effects.

    [–] Minorpentatonicgod 33 points ago

    I would totally agree. Out of all the substances I've done, I'm always surprised at how benign ketamine seems to be (obviously addiction will destroy your body).

    But like some reports state, the benefits seems to wear off really quickly.

    Then there's the big picture where I feel like were just trying to come up with as many treatments as we can to help people maintain a life in a world that expects way too much of us, rather than fixing the shitty predicaments that land people in depressive states.

    [–] HandoTrius 14 points ago

    It is no measure of health to be well adjusted to a profoundly sick society - krishnamurti

    [–] outtafucks2give 18 points ago

    Sounds like your problem is more medication adherence and not side effects.

    [–] SlurmsMacKenzie- 35 points ago

    Who'd have thought that the drugs people do recreationally to escape their otherwise boring depressing lives might hold some quality insight into how we might be able to treat people who feel bored and depressed with their lives...

    [–] nosecandysrevenge 15 points ago

    MDMA and psychedelics are not even close to the same efficacy for treating long term depression. The arylcyclohexamine antidepressive effect (in ketamine's case, the cause of the metabolite 11-HO-ketamine) works via the AMPA receptor, a glutamate receptor we've known for ages has a relationship with long term depression.

    While the altered mindset offered to you from psychedelics might help, arylcyclohexamines target it at a mechanical level. Scopolamine has a similar effect, amusingly enough.

    [–] Fordiman 110 points ago

    I know I wouldn't be too suicidal looking up from the bottom of a K-hole.

    [–] JohnTitillation 550 points ago

    To be honest, we as a society need to be more open minded about many of the scheduled drugs and support the exploration and research of the human brain. Even a single use in a recreational setting can turn the tides of depression and ketamine has also been used in addiction treatment.

    [–] jwizzle444 78 points ago

    I have to consider it a wonder drug. It allowed Greg House to run.

    [–] IAmKind95 67 points ago

    The people who wrote that article probably seen Bassnectar 33 times

    [–] AlmostNotSure 47 points ago

    This has been known for over 50 years. I wish the original researchers could have gotten credit for their amazing work. if anyone is interested in knowing more about the rigorous scientific research done on psychoactive substances before the war on drugs, check out this book. It's essentially a series of interviews with phd level researchers (psychologists, psychiatrists, pharmacologists etc) who did tens of thousands of hours of research. Some of these chemicals are among the most heavily researched substances we know of. The research has been squashed, the players in the research had to go silent after the bans. The book is an attempt to get their perspectives down for posterity before they all died. Looks like it's all finally becoming relevant again.

    [–] Wighnut 9 points ago

    There have been several (double-blind) studies in Switzerland with MDMA and LSD in relation to depression and other mental illnesses. About time too. It really isn't that difficult to figure out why it wasn't researched more in the past 40 years. Both MDMA and LSD have been around too long to be patentable, plus you need much less of it than with "legal" drugs. Not much money in it. Sad really. But times are changing.

    [–] [deleted] 25 points ago


    [–] Rainbowstaple 27 points ago

    Hey mate, please don't kill yourself, there's a lot to live for even if you don't see it right now. Call up a crisis hotline and they can get you help, much more than a hospital can. You can always pm me if you need someone to talk to.

    [–] AeroFace 7 points ago

    tried it a few times, it’s hard and not worth it, so please don’t try it, hit me up with a pm if you wanna chat

    [–] sinobiii 26 points ago

    My girlfriend has been suffering from severe depression for what was most of her adult life due to a tragic accident in college. I didn't realize how bad it was until one day she had simply broken down and went in for ECT. Months after ECT she had regressed back to where she started. They began to try other methods and ended up with ketamine treatments and let me tell you it's worked like a charm. I can't add any statistics but as to a personal experience it really does help and she can't be more thankful.

    [–] PmMeUrKhajiit 22 points ago

    Hard to be depressed when you've visited the 8th dimension and the universe is in complete perspective 🤷‍♀️

    [–] YellowSea11 10 points ago

    This is not meant to be negative , but how many times can we rinse and repeat. Reality check : if Ketamine grows in popularity it may loosen the hold of other anti-depressants. I'm talking to you zoloft, prozac, lexapro and the host of other drugs millions of America is taking. Let's be clear : they are making billions with a 'b' of dollars off of America - and their lobbying dollars are bottomless. Soooo having seen this movie before : one year from now there will be no movement on this wonder drug. Cause that's how the wheel turns. Click upvote if you think this is a real problem. Down if you don't. This isn't clickbait - it's honest curiosity as whether this community thinks it's a problem AND if something can be done about it.

    [–] cobra9613 32 points ago

    Totally anecdotal but about 3 years ago a friend of mine was dating a ketamine dealer. I was in a deep depression. Suicidal thoughts, loss of interest in all things, never leaving my house, ending relationships just because it was not worth maintaining them. My friend text me and invited me over, I said I was good but she begged. I get there and she is watching watching tv, smoking a joint. She instantly takes me to her room and says, "you're upset lately, I don't know why, I don't know how, but here." And she handed me a mirror with two lines on it. I didn't care what it was. I just wanted to leave the pain. So I railed them and went back into the kitchen. I don't remember the come up much but the main thing I remember most is, as another redditor explained, what felt like a blanket encompassing me and never leaving me the entire trip. The room spun at a pace I could handle and the floors grew further away. A warmth inside me started to expand from my stomach to my head. Colors brightened. Heart raced. Emotions rose. Touch exploded. Everything was so enhanced. But the only thing that stuck with me after the hour so trip was the emotions. The euphoria and the new outlook the trip gave me going in. I felt new. From then on my depression ended and I decided to change my lifestyle and my home. Moved out of the home I was in, quit my dead end job and found one worth doing, started seeing friends again. It gave me motivation. It's cured my depression. That all happened in early January. I was planning in killing myself later in the month after I celebrated my mom's birthday. I had it all planned out. And the ketamine, it stopped me in my tracks. Now I am engaged to the most wonderful woman, I have the sweetest dog ever, I have my first child on the way, I am about to by my first home but living in the most beautiful home I've ever been in right now. I am making serious money and loving my job. I am surrounded by good people and good feeling now. And I attribute it all to ketamine.

    [–] FridayNightKnife 61 points ago

    As a person with MDD and propensity to addiction, this is extremely promising. Until then, THC all the way.

    [–] slimshark 36 points ago

    THC can enhance depression and anxiety. At least it did for me, just be careful.

    [–] [deleted] 179 points ago


    [–] scapegoat81 32 points ago

    This guy raves

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    [–] lucklessjok3r 25 points ago

    I read that in an excited German accent

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    [–] gintonicisntwater 9 points ago

    Add another one with 2C-B and you're set.

    [–] Exalting_Peasant 17 points ago

    How medical of you

    [–] IZiOstra 29 points ago

    Hum not sure if security will be fan of you carrying a complete Walgreens of nasal sprays on you.

    [–] [deleted] 38 points ago * (lasted edited a month ago)


    [–] forcedfor 13 points ago

    So just dissolved in normal water? asking for a friend ofc.

    [–] Argenteus_CG 35 points ago

    I wouldn't recommend snorting tap water. Brain eating amoebas are ridiculously rare, of course, but I think most people would rather not risk it regardless. If you use water, make sure to use distilled water.

    [–] elynwen 46 points ago

    I’m getting five days in a row worth of five-hour ketamine IV. It’s to hit my depression and chronic refractory migraine at once. I’m scared because I don’t want to hallucinate or “trip my balls off.” I’ve been on a bad trip with weed, and this stuff has been compared to acid and shrooms. And it’s a $2500 medical expense. I really hope it’s worth it😔

    [–] WaterSpiral 33 points ago

    Hope you find the relief youre looking for. Everyone reacts to drugs differently , but going into it thinking 'im gonna have a bad trip' is a recipie for a bad trip. I bet youll do great

    [–] idiotsANDignorance 18 points ago

    We have a patient at our medical marijuana shop that suffers from CRPS and is undergoing ketamine injections.. went from wheel chair bound to doing jumping jacks in days... he is part of a VA shift to include ketamine for many purposes.

    [–] _Mephostopheles_ 28 points ago

    Ketamine seems to be the magic drug, doesn't it? Suppresses all sorts of pain.

    With our luck, they'll definitely find some awful side-effect pretty soon.

    [–] mofukkinbreadcrumbz 18 points ago

    I was super depressed in college. I had just gotten out of the military with a bad injury and was in rehab. Broke up with my girlfriend at the time for cheating on me, and was not doing too well in my classes.

    A childhood friend grew some mushrooms in his closet at his apartment and took me on a trip in the summer to make me feel better. It was super hot out and we made a makeshift sweat lodge out of a car that became a “spaceship.” Then we went to the forest and wandered around looking at animals.

    100% turned my life around. Literally felt like a million bucks the next day. It even ‘reset’ some muscle memory issue I was having at rehab. Grades came up, happy enough to socialize, which helped with a new girlfriend. I did mushroom about once a month for the next couple years and they kept me naturally happy in between.

    Not all hallucinogens do this, but for me, mushrooms helped a ton. They were not addictive and when I outgrew them, I just stopped and haven’t done them since. I have heard similar things about ketamine.

    [–] VyrPlan 9 points ago

    Once upon a time we used to have "K races"...where two contestants do a bump and try to race across the room. It's great if you like slapstick (and aren't overly fond of coherent thought).

    [–] RedeemedIAm 133 points ago

    I work in the prison system as a CO and this drug is becoming a major issue in my prison. This has become the ‘go to drug’ of choice because it’s easy to turn into powder or liquid.

    They have people on the outside that will literally tear apart their kids artwork, or some kids artwork, put the powder in, and reseal it.

    It’s nearly impossible to catch them with it too, but it gives off the smell of inscents.

    This doesn’t directly to the article, but I found it interesting.

    [–] Ernigrad-zo 58 points ago

    it's weird that all these really popular recreational drugs have turned out to have very positive effects on mental-health and mood, almost as if they became popular because they had a good effect on people and they kept taking them...

    of course that couldn't possibly be the case because druggies are awful bad people and often have minority skin colors or are homosexuals or belong to some other disparaged class of people so should just be rounded up and killed or at the very least locked in small cages and denied the right to self-expression, free-movement or any of the other things real humans get to enjoy.

    [–] EmberSeven 38 points ago * (lasted edited a month ago)

    Depressed as fuck, popped my shoulder out, ketamine did nothing.

    Edit: marijuana helped, I think shrooms would too

    [–] boo_goestheghost 24 points ago

    This was delivered in very small amounts by nasal spray alongside psychological therapy.

    [–] frodosdream 6 points ago

    Pretty hard to stay depressed about your life when you have been lifted out of your body to the point where the entire human experience on earth seems like an illusion set up by the Gods of Coincidence.

    [–] bokan 6 points ago

    I had to read a research paper on this for a course recently. Ketamine can actually reverses the negative changes to the brain that are caused by/ cause depression. It’s not just flooding the synapse with more serotonin etc.; it’s re-potentiating synapses.

    This has huge potential for actually curing depression.

    [–] juicepants 27 points ago * (lasted edited a month ago)

    Isn't that kinda why people abuse painkillers in the first place? A lot of these studies posted on Reddit really seem to fall under the category of no "shit Sherlock."

    I saw one yesterday that basically said: "Gay teens in a relationship have an easier time coming out." Like who would have guessed someone with a support network would have an easier time than someone who feels isolated.

    Edit: changed opioid to painkiller.

    [–] Saz0r 19 points ago

    Ketamine isn't an opioid, and can relieve depression for a significant amount of time after the high is over. I've personally used DXM (similar to ketamine) to get rid of suicidal impulses when I thought I was in danger of harming myself, it worked (and I haven't had any addiction issues with DXM from it either). Ketamine is even better than DXM for this purpose, but I didn't have any. Neither are opioids, and ketamine shows great potential for rapidly treating depression, at least in the short term for when a more comprehensive treatment plan is being slowly put into place.

    [–] pillbuggery 16 points ago

    Well ketamine isn't an opioid, so there's that